Nicotine Replacement Therapy (NRT) & Fertility  |  Reproductive Science Research

Nicotine Replacement Therapy (NRT) & Fertility | Reproductive Science Research

Nicotine gum can potentially have negative effects on fertility for both men and women, though the impacts are generally less severe compared to smoking cigarettes.

For women:

Nicotine exposure through gum may disrupt hormone regulation and affect ovulation[1][2]. - It could potentially reduce uterine receptivity, making implantation of an embryo more difficult[1][2]. - Nicotine may damage fallopian tubes by altering gene expression[4].

For men: 

Nicotine from gum can reduce sperm motility and fertilization capacity[3][4]. - It may lower sperm count and semen volume[3][4]. - Nicotine exposure is associated with DNA fragmentation in sperm, which can prevent successful fertilization[3][4].

NRT is still considered a safer alternative

While nicotine gum delivers lower doses of nicotine compared to cigarettes, it still introduces nicotine into the body. This can impact reproductive functions, albeit likely to a lesser degree than smoking.

However, nicotine gum is generally considered a safer alternative for those trying to quit smoking while attempting to conceive[1][2].

If fertility is a concern, it's best to consult a doctor about using nicotine replacement therapy. Ideally, completely quitting nicotine use would be most beneficial for optimizing fertility for both men and women[1][2][3]. 

Sources

[1] Effects of Nicotine on Sperm Characteristics and Fertility Profile in ... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719292/ 

[2] An Overview of E-Cigarette Impact on Reproductive Health - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053939/ 

[3] Smoking and infertility: a committee opinion - ScienceDirect.com https://www.sciencedirect.com/science/article/pii/S0015028218304928 

[4] Smoking, Pregnancy and Fertility - ASH https://ash.org.uk/resources/view/smoking-pregnancy-and-fertility 

[5] How Smoking Can Affect Fertility | NICORETTE® https://www.nicorette.co.uk/getting-ready-to-quit/smoking-and-fertility